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In this class, we have come to understand, time and time again, the importance of proteins on biological systems. I would like to focus my analysis of the seventh edition of Biology, written by Neil Campbell and Jane Reece, on the chapters concerning the creation of proteins from transcription and translation. I found this part of the course to be particularly interesting, and feel that this section provides a solid basis for comparison between the approaches of the book and the course. Chapter 17 is titled “From Gene to Protein,” and promises by the end of the section that the reader will, “understand how genetic mutations, such as the one causing the dwarf trait in pea plants, affect organisms through their proteins” (2, 309). This section corresponds with our discussion from the week starting October 30th, during which we discussed the process of creating polypeptide chains, and in turn, the creation of proteins.
Chapter 17 of the text book begins with the history of the research done to determine the processes of transcription and translation, the two major stages required to create proteins from DNA (2, 311). It then acknowledges that this research is part of an ongoing “story” which allows for revisions of the current hypothesis in the future. After providing the initial background context, the book delves into the explanations for each process. The book goes into much greater detail than was covered in class, however, it is important to keep in mind the goals of the course compared to the goals of the text book. In Biology 103, we were attempting to gain a basic understanding of concepts related to the study of biology, whereas a student relying on this text book would probably be looking for introductory knowledge in order to advance to the next level. Overall, I find that the use of the internet and the online lecture notes Professor Grobstein provided to be a more effective teaching method for our purposes. While I would never wish to minimize the value of reading to gain a better understanding, the online website is a more accessible source of information for those wishing to gain a better understanding of the world around them, rather than memorizing a bunch of processes and facts relating to biology.
While I found the website to be a better method for teaching than the text book in this particular chapter, there are several features of the book that I feel parallel or vary from the format of our course. The use of pictures and figures in the text provide for a more in depth understanding of the concepts being discussed in the text. These are much like the links provided on the site along side Prof Grobstein’s bullet points. Students are able to go back to the site on their own time and further explore provided sites, just as they are capable of examining the figures and captions. The book also puts key terms and concepts into bold font and they are defined in the back of the book in the glossary. These would be helpful for review of the section and a limited understanding of the chapter. Each chapter is also broken down into sections, and at the end of each section there is a “concept check” containing a couple questions to ask oneself. In addition, at the end of every chapter, there is a multiple choice, 10 question quiz, for which answers are provided in the Appendix. After reading the chapter, the questions were not difficult to answer, but were helpful in providing some sort of self-evaluation. That was one of the major differences between the book and the structure of the course. There was not a lot of opportunity in the course to evaluate how well you had understood concepts taught in class, at least in the traditional sense of examinations, such as quizzes or tests.
All of these features reflect two very different philosophies of teaching. Rather than teaching for a test, and requiring rigid memorization, Professor Grobstein’s structure of the class encouraged participation in the course forum to express concerns and thoughts. The class fostered individual expression and ideas and instead of responding to a text, we were responding to each other. While the text book provides much material for a greater understanding of biology, the students provided each other with research on interesting topics from different sources. Mariellyssa writes during the week we were discussing proteins, “Although class this past week was interesting, I did find it a bit hard to follow. I spent some time this weekend reading about fat and cholesterol levels and how they effect our bodies… I found this great article by the Harvard School of Public Health that was really interesting, you should check it out” (1, Mariellyssa, 11/5/2006) . Not only did she take the initiative to learn more about the subject and educate herself, rather than waiting to be taught, she was able to provide the rest of the students, and anyone reading our course forum, the opportunity to learn more as well. While I think that the two forms of learning achieve similar goals in the end, the student has a much different educational experience.
Overall, I felt that in the authors’ attempt to break the material down into manageable sizes, a student easily loses sight of the big picture. It would be difficult for a student really absorbed in the facts of the material to take a step back and appreciate the really wonderful processes occurring in biology, as our class was often able to do. An example of this is very clearly expressed in the forum, “It is really amazing that the slightest changes in the assembly of atoms or in a molecule can lead to things as different as a human and a rock… To think, any one of us could be affected with a serious disease because of a ‘malfunction’ of DNA, the smallest things that make up our body” (1, Kelly, 11/6/2006). Especially in this chapter, which is dealing with genetic makeup on such a miniscule level, one does not get a full appreciation for the tiny changes along the polypeptide chain which result in the expressed genetic mutations. I found the book to provide a wealth of information, much of which was not even covered by the class lectures, but I gained a better appreciation for the implications of science in my everyday life than I otherwise would have in a different course.


Works Cited

In June 1999, it was reported that the prevalence and severity of asthma had increased over the past twenty years, the biggest sufferers being children and young adults located in inner-cities of the US (5). This trend has intensified in recent years, and further studies show that children of low-income families are disproportionately affected by asthma. There are many factors involved in one’s susceptibility to the disease and it is important to understand the causes and triggers of asthma to more clearly see why children in cities are at such high risk. As the problem has gained more attention, the government has taken on initiatives in order to improve the problem, including programs to help educate parents and healthcare providers about dealing with asthma in children. Asthma is a classic example of the interaction between genes and environment and is an important disease to understand in terms of both its scientific and social implications in this country (5).

Of all the improbable biological organizations in existence, the brain is perhaps the least probable. In her book Mapping the Mind, Rita Carter describes how everything we do, sense, experience, and are is processed through intricate interactions in the brain. Despite advances in the relatively new scientific field of brain mapping, the brain "is probably so complex that it will never succeed in comprehending itself"(10). However, in classes such as Biology 103, scientists with all levels of experience continually attempt to form a "less wrong" understanding of the brain not only by using it but also by imitating it. The brain itself is a scientist that tests hypotheses and is always inventing better stories to use to interact with the world around it. Through evolution, the brain has caused humans to emerge as "Story Tellers," conscious life forms with the ability to question and to create. Mapping the Mind asks many of the same questions about the brain that we have asked about science in Biology 103. These include the effects of architecture on life, the use of "seriously loopy science," and the rise of consciousness from matter.

If humans had to migrate yearly from one spot on the globe to another thousands of miles away in order to find adequate food and to reproduce, and if the only navigational tools available were landmarks, the earth's magnetic field, the sun and the stars, most people would not have a strong enough sense of direction to make the trip. Yet migratory birds accomplish just this feat twice a year when they travel to their wintering grounds and back to their summer habitats. Each bird has the ability to utilize more than one of the above devices to navigate its way north and south. The urge to migrate at certain times yearly, and even the direction in which to start off in, may be programmed directly into the genes of migratory birds, but is affected by their environment and can be changed through evolution. The migratory "sense" that birds seem to possess seems like a sixth sense, difficult for humans to imagine. It turns out to be a combination of many different factors that birds have learned, throughout the evolutionary process, to interpret.

       

       Every biological occurrence has an explanatory story; unfortunately, not all of them end in happily ever after. Once upon a time, there lived a middle aged woman who happened to be the Queen of England. Mary – or as history would crown her, Bloody Mary Tudor – fell in love with handsome Phillip, the prince of Spain and twelve years her junior. As custom dictated, Mary and Philip married in a lavish ceremony, and soon after Mary fell pregnant. As Mary had been facing the pressure of producing an heir to the throne, the event could not have been better timed. The Queen was ecstatic as she watched her belly swell with life, her long awaited heir. Except…nine months came and went, then twelve months, then fifteen months. It became painfully obvious that Mary had never been pregnant, despite her distended abdomen and lactating breasts[1]. Needless to say, Mary was depressed, her physicians were perplexed, and historians were intrigued. How could a woman’s body simulate a physical pregnancy, with no medical aid whatsoever? What was this powerful mind-body connection in which desire and sheer will could create a pregnancy without a fetus? Such were the questions behind the story of pseudocyesis.             Pseudocyesis, or false pregnancy, is a medical phenomenon in which women (and a few men, it has been reported) experience all the symptoms of pregnancy without actually being pregnant. Those affected by this disorder exhibit amenorrhea (the discontinuation of menstruation), tender and swollen breasts, distended abdomen, morning sickness, and even “fetal movement”[2]. In very rare cases, a woman may even experience labor pains and phantom delivery. What makes the body so fervently believe it is carrying and birthing a child, when in fact there is nothing but air?            Typically, this condition occurs in thirty-something women (though some cases have reported both female children and more mature adults). Statistics show that 80% percent of women with the condition are married, 14.6% are single, and 2.3% are widowed; at least one third of them have been pregnant before.3 Pseudocyesis manifests itself when a woman is either:

1. desperately wanting a child, because of a basic biological or emotional need
2. extremely afraid of becoming pregnant, or giving birth
3. suffering from a severe depressive disorder. [3]

Above all, pseudocyesis is a psychological condition occurring when a woman’s overpowering fears or needs of pregnancy manifests. It is believed that this psychological desire or depression triggers the pituitary gland to secrete elevated hormones, mimicking the hormone changes of real pregnancy[4]. Similarly, the body accumulates increased amounts of gas, fat, feces, or urine to mimic the swollen belly. Women who have been trying to conceive for long periods of time to no avail (either because of infertility or miscarriage) develop severe depression, and couple with their intense longing for a child, trick their bodies into “becoming” pregnant. The physical changes in their bodies coupled with the strength of their delusion can result in false positive pregnancy tests. When these women undergo routine prenatal procedures such as sonograms, and are told by physicians of their condition, they refuse to believe that they are not truly expecting. As time goes by and no child is born, however, they must face the reality of their situation; sometimes they fall into clinical depression. Pseudocyesis usually lasts nine months, although it can last as little as a few months or many years. 1% of women with this condition go so far as to actually experience labor pains, and need to “deliver” their non-existent child. Fortunately, cases of pseudocyesis have declined with time; advancements in technology and psychology make diagnosing this condition easier, as well as offering more efficient treatment. Currently 1 to 6 cases per 22,000 births are reported in the United States, a steady decline from the 156 cases reported between 1890 and 1910[5]. This condition is most commonly known and observed among non-human mammals, especially dogs and cats. In that instance, the animal will begin to nest, preparing a home and birthing space for themselves; they might also gain weight, produce milk, and “mother” inanimate objects. Canine pseudocyesis can manifest itself both overtly and covertly – if the animal exhibits physical symptoms of pregnancy it is overt pseudocyesis, if they exhibit no physical symptoms but show expecting behavior, it is covert[6]. Some animals may “undergo” this phantom pregnancy in order to be able to lactate and feed abandoned young from their tribe; it is also a response to their ovulation cycles. These animals suffer from the same desire their human counterparts do: they do not merely want offspring, but they yearn passionately for them. Unlike humans, however, once a canine experiences pseudocyesis, the condition is likely to return over time.             The usual course of treatment for women with pseudocyesis is intense therapy sessions, as well as medical procedures to “cure” them of their conditions. To terminate their distended bellies, they are placed under general anesthesia; for the amenorrhea and elevated hormone levels, they are prescribed certain medicines. Alternative medicine such as massages, hypnosis, and opiates are also employed as a course of treatment, but their effectiveness is not proven. Usually the extinction of their physical symptoms, and a sonogram, partly resolves the situation; however, psychotherapy is the best recourse to ensure the restoration of their mental health.[7]            Many people believe we exist in order to reproduce: to create more life, and increase the chance of “getting it right” this time around. Consequently, we also believe that immortality is truly only achieved through procreation – a small part of ourselves will live on in our children and our children’s children. Women in particular have been instilled with the notion that their sole role is that of a mother, increasing the pressure of having children. Pseudocyesis has perhaps decreased because the roles we now “offer” women are vaster: self-accomplishment can be achieved through excelling in professions, education, charity work, and spiritual endeavors. Mary Tudor never did have children, and that is not the reason for which she is remembered: Mary fought for her crown, her government, her faith, and her people. She is a reminder that one does not have to have children in order to be a woman. The story of pseudocyesis might never be complete for we still do not fully comprehend the causes or treatment for this condition. Its existence, however, allows us to observe the intensity and power of the mind over body: our greatest desire or fear can affect our corporeal composition and harmony. How to know how much of our ailments or experiences are controlled by the mind, how much it can cure? We are left in the darkness of the unknown, comforted only by the infinitesimal possibilities our mind can accomplish.

Over 11 million people are diagnosed with cancer world wide each year, 7 million of which will not survive. With early detection, one-third of all cancers can generally be cured by surgery, chemotherapy or radiotherapy (1). Nonetheless, cancer treatment and detection is amongst the biggest medical challenges faced by our societies today.  Ever since the late 1980s there have been reports, articles and stories about “cancer defying sharks” and how these fearful predators potentially hold the secret weapon in our fight against cancer. These stories were commercially publicized by an entrepreneur named I. William Lane, who claimed that shark cartilage could treat and cure cancer, arthritis, enteritis (an inflammation of the intestinal tract), macular degeneration, psoriasis, acne and poison ivy (2). These claims became widely publicized and many companies in the US began marketing these shark cartilage “supplements”. Oncologists also noticed that an increasing amount of their patients were asking about shark cartilage treatments or had already tried this form of alternative therapy (3). Many were so eager to believe the idea of finding such an idealistic cure for cancer, that they did not bother to search for the scientific evidence supporting the alleged “magical properties” of powdered shark cartilage.

How do flying fish fly?

Or

What makes flying fish so special?

 

            As a kid, I was always enchanted by flying fish.  They seemed so wrong in the world – fish, that live and breathe and eat and breed in water, flying in the sky like birds.  For years, I didn’t think flying fish actually existed.  But I began to believe, little by little, and now have decided to base my final web paper on these magnificent creatures.  Where exactly do they live?  What exactly do they look like?  How exactly do they live?  Why exactly do they fly?

Synesthesia
12/7/2006
Annabella Wood
Bio Paper Three

Do you hear color? Do you see sounds? If so, does a certain sound have a certain color?
Can you taste sounds? Do you hear a sound when you touch a certain texture? If so,
chances are, you are a synesthete.

But take heart, you are not alone. Synesthesia is actually very common by some
standards. Estimates range from 1 in 100,000 (1) to 1 in 100(2) people are synesthetes.
But the fact that this range is so wide tells us that we really don’t know how many
synesthetes there are.

This semester I have learned a lot about biology, from both the book I read and the course itself. I used to think I knew everything because all I ever had to do was memorize some facts and that was the end of it. Upon entering this biology course the first thing I heard was that nothing in science, any branch of science, is absolute. How could science not be absolute? Was everything I had previously learned a lie? I had no idea what to do, so I decided to do what was instructed on the first day of class- throw out everything I learned before and start over.

As the course progressed, I found that it was much easier for me to learn everything over again with a new perspective. I did not have to be right all the time because it was even better to be wrong and then try to find out why I was wrong. But even those words, "right and wrong", held little meaning in this course. The most important thing I learned about biology from the course was that it is not about getting it right, it is about getting it less wrong.

Every look, every gesture, every twitch of an eyebrow, communicates an inaudible message.  This form of communication is just as important in the understanding of how humans interpret other’s emotions and intentions as the study of verbal language. In many instances, reading the movements of the body can be a more effective and accurate form of communication than words. For example, many of us find it very helpful to give or receive directions by signaling to right and left turns with our arms. Even if for the most part, we are unaware that we are doing so. This form of non-verbal communication, which has been widely studied in social and popular psychology, is commonly known as body language. It includes posture, facial expression and gestures in a manner in which a person voluntarily or involuntarily manifests his or her aspirations. (1)