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Next Generation Science Standards - Activity LIsting

Many of our activities for helping middle school and high school students learn life sciences are aligned with the Next Generation Science Standards (NGSS; http://www.nextgenscience.org/next-generation-science-standards). The following listing provides brief descriptions of our NGSS-related resources. The tables in Alignment of Activities with Next Generation Science Standards summarize the alignment of our activities with NGSS Disciplinary Core Ideas and Performance Expectations. These tables also summarize how each of these activities engages students in Scientific Practices and provides the opportunity to discuss Crosscutting Concepts. The Teacher Notes for each activity provide additional information concerning alignment with the Next Generation Science Standards.

Food Webs, Energy Flow, Carbon Cycles, and Trophic Pyramids

Food web with plants and animals

To begin this hands-on, minds-on activity, students view a video about changes in the ecosystem that resulted when wolves were eliminated from Yellowstone National Park and decades later returned to Yellowstone. Students learn about food chains and food webs, and they construct and analyze a food web for Yellowstone. Then, students use what they have learned to understand a trophic cascade caused by the elimination of wolves from Yellowstone.

Next, students learn that the biosphere requires a continuous inflow of energy, but does not need an inflow of carbon atoms. To understand why, students apply fundamental principles of physics to photosynthesis, cellular respiration, and biosynthesis, the processes which result in carbon cycles and energy flow through the biosphere.

Finally, students use the concepts they have learned to understand trophic pyramids and phenomena such as the relative population sizes for wolves vs. elk in Yellowstone. Thus, students learn how ecological phenomena result from processes at the molecular, cellular, and organismal levels.

Food, Physical Activity, and Body Weight

This analysis and discussion activity helps students to understand the relationships between food, physical activity, cellular respiration, and changes in body weight.

Analysis of a representative scenario helps students to understand how challenging it is to prevent weight gain by exercising to offset what seems to be a relatively modest lunch.

The Student Handout is available in the first two attached files. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.

Gene Editing with CRISPR-Cas – A Potential Cure for Severe Sickle Cell Anemia

This analysis and discussion activity introduces Victoria Gray whose severe sickle cell anemia was effectively treated by gene editing with CRISPR-Cas.

To begin, students review the molecular biology of sickle cell anemia, transcription and translation.

Next, they learn how bacteria use CRISPR-Cas to defend against viral infections and how doctors use CRISPR-Cas to treat sickle cell anemia. Then, students examine some of the research findings that scientists used to identify their target for gene editing.

Finally, students analyze the CRISPR-Cas gene editing treatment for sickle cell anemia.

Genetic Engineering Challenge – How can scientists develop a type of rice that could prevent vitamin A deficiency?

Parts of rice diagram

This analysis and discussion activity begins with an introduction to vitamin A deficiency and a review of transcription, translation, and the universal genetic code.

Several questions challenge students to design a basic plan that could produce a genetically engineered rice plant that makes rice grains that contain pro-vitamin A. Subsequent information and questions guide students as they learn how scientists use bacteria to insert desired genes, together with an appropriate promoter, in the DNA of plant cells.

In a final optional section, students evaluate the pro and con arguments in the controversy concerning Golden Rice.

Genetics

Photo of albino and non-albino children

This hands-on, minds-on activity helps students to understand basic principles of genetics, including (1) how genotype influences phenotype via the effects of genes on protein structure and function and (2) how genes are transmitted from parents to offspring through the processes of meiosis and fertilization.

Students use model chromosomes to demonstrate how meiosis and fertilization are summarized in Punnett squares.

In the coin flip activity, students learn about the probabilistic nature of inheritance and Punnett square predictions.

Genetics and Probability – Sex Ratios of Births

In this minds-on analysis and discussion activity, students analyze the inheritance of sex chromosomes. Students use a Punnett square to predict the sex ratio of births and compare their prediction to data for individual families and for the entire US.

As students analyze the reasons why many real families deviate from Punnett square predictions, they learn about the probabilistic nature of inheritance and the limitations of Punnett square predictions.

Genetics – Major Concepts, Common Misconceptions, and Learning Activities

Part I summarizes key concepts in genetics. Part II presents common misconceptions. Part III recommends an integrated sequence of learning activities on the biological basis of genetics, plus seven human genetics learning activities. These learning activities develop student understanding of key concepts and counteract common misconceptions. Each of these recommended learning activities supports the Next Generation Science Standards (NGSS).

How Animals Adapt to Their Environments– Examples and Evolution

In this activity, students analyze examples of adaptations, including camouflage, mimicry of an inedible object, and phenotypic plasticity. Phenotypic plasticity means that a single genotype can develop different phenotypes in different environments.

Phenotypic plasticity allows an individual organism to adapt to different environments during its lifetime. Natural selection for an adaptation allows a population of organisms to adapt to different environments over time.

The Student Handout is available in the first two attached files and as a Google doc designed for use in online instruction and distance learning. The Teacher Notes, available in the last attached file, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards. The last attached file is a Powerpoint of the figures so you can show your students the color camouflage.




How do food molecules reach our muscles? – Structure and Function of Organ Systems, Organs and Cells

In this activity, students learn (1) how food is digested into smaller molecules and (2) how the digestive and circulatory systems cooperate to bring digested food molecules to muscles all over the body.

Students analyze several examples of the relationship between structure and function in these organ systems.

Finally, students use a claim, evidence, reasoning framework to evaluate the claim that structure is related to function in cells, organs and organ systems.

Two versions of the Student Handout are available – a more complete version (suitable for most high school students) and a simpler version (suitable for most middle school students).

How do muscles get the energy they need for athletic activity?

ATP in muscle cells

In this analysis and discussion activity, students learn how muscle cells produce ATP by aerobic cellular respiration, anaerobic fermentation, and hydrolysis of creatine phosphate. Students use their understanding of these three processes to analyze their relative importance when racing different distances.

Students learn how multiple body systems work together to supply the oxygen and glucose needed for aerobic cellular respiration.

Finally, students use what they have learned to analyze how regular aerobic exercise can improve athletic performance.

The Student Handout is available in the first two attached files and as a Google doc designed for use in distance learning and online instruction. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.


How do organisms use energy?

Enzymes convert substrates to product

This analysis and discussion activity introduces students to the basic principles of how organisms use energy.

Students learn that, in cellular respiration, glucose is one input for reactions that provide the energy to make ATP. The hydrolysis of ATP provides the energy for many cellular processes.

Students apply the principles of conservation of energy and conservation of matter to avoid common errors and correct common misconceptions.

The Student Handout is available in the first two attached files and as a Google doc designed for use in distance learning and online instruction. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.

How do we sense the flavors of food?

In this minds-on, hands-on activity, students learn how flavor perception depends on sensory input from taste and smell receptors.

Students develop their science practice skills by planning and carrying out an investigation and interpreting the results.

Students also learn that sensory input is processed by the brain to stimulate perception and behavior.

Download Student Handout: PDF format or Word format

Download Teacher Preparation Notes: PDF format or Word format

The Teacher Preparation Notes recommend supplies, provide instructional suggestions and background information, and explain how this activity is aligned with the Next Generation Science Standards.

We invite your comments and questions. If you would prefer to send your comments or questions in a private message, please write Ingrid Waldron at iwaldron@upenn.edu. 

How does evolution result in similarities and differences?

Earthword, mealworm,and cricket

In this hands-on, minds-on activity, students analyze the similarities and differences between bat and squirrel skeletons and between bat and insect wings.

Students learn about the two ways that evolution produces similarities: (1) inheritance from shared evolutionary ancestors (homologous characteristics) and (2) independent evolution of similar characteristics to accomplish the same function (analogous characteristics).

In the laboratory investigation, students observe the external anatomy and locomotion of earthworms, mealworms, and crickets. Students use these observations and the concepts they have learned to figure out which two of these animals are more closely related evolutionarily. (NGSS)

Download Student Handout: PDF format or Word format

Download Teacher Preparation Notes: PDF format or Word format

How Eyes Evolved – Analyzing the Evidence

Human eye and octopus eye with lens and retina

This analysis and discussion activity focuses on two questions. How could something as complex as the human eye or the octopus eye have evolved by natural selection? How can scientists learn about the evolution of eyes, given that there is very little fossil evidence?

To answer these questions, students analyze evidence from comparative anatomy, mathematical modeling, and molecular biology. Students interpret this evidence to understand a likely sequence of intermediate steps in the evolution of complex eye and how each intermediate step contributed to increased survival and reproduction.

The Teacher Notes suggest additions to the Student Handout that can be used to introduce concepts such as the role of gene duplication in evolution and/or homology and analogy. 

The Student Handout is available in the first two attached files. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards and the Common Core State Standards.

How Genes Can Cause Disease - Introduction to Transcription and Translation

Process of transcription and translation

To begin this hands-on, minds-on activity, students learn that different versions of a gene give the instructions for making different versions of a clotting protein, which result in normal blood clotting or hemophilia.

Then, students learn how genes provide the instructions for making a protein via the processes of transcription and translation. They develop an understanding of the roles of RNA polymerase, the base-pairing rules, mRNA, tRNA and ribosomes.

Finally, students use their learning about transcription and translation to understand how a change in a single nucleotide in the hemoglobin gene can result in sickle cell anemia.

Throughout, students use the information in brief explanations, figures and videos to answer analysis and discussion questions. In addition, students use simple paper models to simulate the processes of transcription and translation.

An alternative version omits the paper models (How Genes Can Cause Disease – Understanding Transcription and Translation).

Download Student Handout: PDF format or Word format

How Genes Can Cause Disease – Understanding Transcription and Translation

Transcription with RNA nucleotides

In the first section of this analysis and discussion activity, students learn that different versions of a gene give the instructions for making different versions of a clotting protein, which result in normal blood clotting or hemophilia.

Next, students learn how genes provide the instructions for making a protein via the processes of transcription and translation. They develop an understanding of the roles of RNA polymerase, the base-pairing rules, mRNA, tRNA and ribosomes.

Finally, students use their learning about transcription and translation to understand how a change in a single nucleotide in the hemoglobin gene can result in sickle cell anemia.

Throughout this activity, students use the information in brief explanations, figures and videos to answer analysis and discussion questions.

This activity can be used to introduce students to transcription and translation or to reinforce and enhance student understanding. 

If you prefer a hands-on activity that uses simple paper models to simulate the molecular processes of transcription and translation, see “How Genes Can Cause Disease – Introduction to Transcription and Translation” (http://serendipstudio.org/sci_edu/waldron/#trans).

How have mutations and natural selection affected fur color in mice?

Four differently colored mice

In this analysis and discussion activity, students figure out how mutations and natural selection have resulted in matches between the fur colors of populations of rock pocket mice and their environments.

Next, students view a video that presents relevant research findings, and students answer the embedded multiple-choice questions.

Then, students answer multiple questions and analyze several scenarios to enhance their understanding of mutations and natural selection.

The Student Handout is available in the first two attached files and as a Google doc designed for use in online instruction and distance learning. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity is aligned with the Next Generation Science Standards.

How Meiosis and Fertilization Produce Genetic Diversity (In Contrast to Asexual Reproduction)

In this analysis and discussion activity, students learn how meiosis produces genetically diverse gametes, by analyzing the results of crossing over and independent assortment.

Students figure out why no two siblings (except identical twins) have exactly the same alleles.

A final section contrasts sexual reproduction with asexual reproduction.

How Mistakes in Meiosis Can Result in Down Syndrome or Death of an Embryo

In this minds-on analysis and discussion activity, students learn how a mistake in meiosis can result in Down syndrome. Students also analyze karyotypes to learn how other mistakes in meiosis can result in the death of an embryo. Finally, students consider how a health problem can be genetic, but not inherited.

The Student Handout is available in the first two attached files and as a Google doc designed for use in online instruction and distance learning. The Teacher Notes, available in the last two attached files, provide instructional suggestions and background information and explain how this activity supports the Next Generation Science Standards (NGSS).

Introduction to Genetics – Similarities and Differences between Family Members

In this analysis and discussion activity, students learn that different versions of a gene give the instructions for making different versions of a protein which can result in different characteristics.

Additional questions guide students as they review how genes are transmitted from parents to offspring by the processes of meiosis and fertilization.

Then, students analyze several examples that illustrate how inheritance of genes can result in similarities and differences between family members.

Concepts covered include Punnett squares, dominant and recessive alleles, incomplete dominance, and polygenic inheritance. These concepts are reinforced in an optional final review page.