In 1971 a question posed by Linda Nochlin changed the way art history was viewed. Her essay “Why Have There Been No Great Female Artists” explores the reasons for the severe disproportion of female to male artists throughout the course of art history (1). While this is undeniably at least in part an issue of social concern, the may be more than one answer. It is possible that art history and neurobiology can, in fact, over-lap. There are irrefutable physical, hormonal, and genetic differences between women and men. More importantly, aside from these primary and secondary sex-differences there are a wide variety of sometimes subtle, sometimes prominent neurological differences, from basic neural organization to the way female and male brains process everyday information (4). There are evolutionary advantages to having differences between the female and male members of a species. These differences in no way imply and superiority or inferiority between the sexes, especially in humans (4). In people, there is much more overlap in these dissimilarities, due largely to the fact that our own brain structure is largely malleable and able to be easily manipulated and changed due to our higher functional capabilities. It seems pertinent to investigate the fact that the reason there are “no great female artists” might because of biological differences in the creative process or ability to produce art.