In this minds-on, hands-on activity, students develop science practice skills by developing plans for a hands-on investigation, carrying out the investigation, analyzing the data, and interpreting the results.

Then, students answer analysis and discussion questions as they develop a basic understanding of how taste and olfactory receptor cells function and how sensory messages to the brain contribute to flavor perception and flavor-related behavior.

This minds-on, hands-on activity begins with an anchoring phenomenon, how a person’s breathing changes when he/she is re-breathing the air in a plastic bag. Students develop a negative feedback model of how the changes in breathing stabilize blood levels of O2 and CO2.

Then, students use a negative feedback model to understand temperature regulation, homeostasis, and how a change in setpoint can result in a fever.

Next, students analyze how failures of negative feedback regulation of blood glucose levels can result in diabetes.

Finally, students compare and contrast positive and negative feedback. Throughout this activity, students learn relevant human physiology.

An Appendix for the Teacher Preparation Notes suggests an optional activity in which each student group investigates a question or hypothesis concerning negative feedback, homeostasis and changes in breathing. 

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In the lab, Regulation of Human Heart Rate, students learn how to measure heart rate accurately. Then students design and carry out an experiment to test the effects of an activity or stimulus on heart rate, analyze and interpret the data, and present their experiments in a poster session. In this activity students learn about both cardiac physiology and scientific method.

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In the lab, Invertebrate Diversity, students compare the external anatomy and locomotion of earthworms, mealworms, crickets and crayfish, all of which can be purchased at low cost from local pet stores.  Discussion questions help students understand the evolutionary basis of observed similarities and differences. This activity can be used as an introduction to the Annelid and Arthropod phyla and the principle that form matches function.

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First, students analyze a hypothetical example of exponential growth in the number of infected individuals.

Then, a class simulation of the spread of an infectious disease shows a trend that approximates logistic growth.

Next, students analyze examples of exponential and logistic population growth and learn about the biological processes that result in exponential or logistic population growth.

Finally, students analyze how changes in the biotic or abiotic environment can affect population size; these examples illustrate the limitations of the exponential and logistic population growth models. 

In this minds-on, hands-on activity, students develop their understanding of natural selection by analyzing specific examples and carrying out a simulation. The questions in the first section introduce students to the basic process of natural selection, including key concepts and vocabulary.

The second section includes a simulation activity, data analysis, and questions to deepen students' understanding of natural selection, including the conditions that are required for natural selection to occur. 

In the third section, students interpret evidence concerning natural selection in the peppered moth and answer questions to consolidate a scientifically accurate understanding of the process of natural selection, including the role of changes in allele frequency. 

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Download Teacher Preparation Notes: PDF format or Word format

In this hands-on, minds-on activity, students extract DNA from Archaea or from their cheek cells.

In addition, students learn or review key concepts about the structure, function, and replication of DNA. For example, students learn that the genes in DNA give the instructions to make proteins, which influence our characteristics.

They also learn how the double helix structure of DNA and the base-pairing rules provide the basis for DNA replication.

This activity includes multiple analysis and discussion questions and hands-on or online modeling of DNA replication. (NGSS)

 Download Student Handout Archaea: PDF format or Word format

Download Teacher Preparation Notes Archaea: PDF format or Word format

Download Student Handout Cheek Cells: PDF format or Word format

Download Teacher Preparation Notes Cheek Cells: PDF format or Word format

In this minds-on, hands-on activity, students learn about the genetics of ABO blood types, including multiple alleles of a single gene and codominance. Then, students use chemicals to simulate blood type tests and carry out genetic analyses to determine whether hospital staff accidentally switched two babies born on the same day.

Next, students analyze the genetics of skin color in order to understand how fraternal twins can have different skin colors. In this analysis, students learn about incomplete dominance and how a single phenotypic characteristic can be influenced by multiple genes and the environment. (NGSS)

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Download Teacher Preparation Notes: PDF format or Word format